BDBM50069989 (R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid::(R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-6-carboxamido)propanamido)butylboronic acid::BORTEZOMIB::CHEMBL325041::Dipeptidyl boronic acid derivative::LDP-341::N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE::PS-341::Peptidyl boronic acid derivative::US11542283, Compound Velcade::Velcade::cid_387447
SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O
InChI Key InChIKey=GXJABQQUPOEUTA-RDJZCZTQSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50069989
Affinity DataIC50: 1.88E+3nMAssay Description:Inhibition of trypsin-like activity of human 20S proteasome beta 2 subunit using Ac-RLR-AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 590nMAssay Description:Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta2 after 30 mins by fluorogenic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 440nMAssay Description:Inhibition of trypsin-like activity of 20S proteasome in human HL60 cells using Z-LRRaminoluciferin as substrate pretreated for 2 hrs followed by sub...More data for this Ligand-Target Pair
Affinity DataIC50: 440nMAssay Description:Dissociation constant against galectin-3 using competitive fluorescence polarizationMore data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of trypsin-like activity of human 20S proteasomeMore data for this Ligand-Target Pair
Affinity DataIC50: 1.93E+3nMAssay Description:Inhibition of trypsin-like activity of human 20S proteasome using Boc-LRR-MCA as substrate measured for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of trypsin-like activity of human 26S proteasome using Boc-LRR-MCA as substrate measured for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 128nMAssay Description:Inhibition of human 20s proteasome subunit beta2 caspase-like activity using Z-LLE-AMC as substrate preincubated for 15 mins followed by substrate ad...More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of 20S proteasome beta 2c (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.12E+3nMAssay Description:Inhibition of human hepatic cell derived 20s constitutive proteasome beta2 trypsin-like activity using Suc-LLE-AMC as substrate preincubated for 15 m...More data for this Ligand-Target Pair
Affinity DataIC50: 2.12E+3nMAssay Description:Inhibition of human hepatic cell derived 20s constitutive proteasome beta2 trypsin-like activity using Suc-LLE-AMC as substrate preincubated for 15 m...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human 20S constitutive proteasome beta 2 subunit trypsin-like activity using fluorogenic peptide Ac-WLR-AMC as substrate in presence of...More data for this Ligand-Target Pair
Affinity DataIC50: 261nMAssay Description:Inhibition of 20S proteasome beta2 subunit (unknown origin) using Boc-LRR-AMC as flurogenic substrate measured after 1 hr by fluorescence based analy...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human platelet Thromboxane synthetaseMore data for this Ligand-Target Pair